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The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 190-200 doi: 10.1007/s11684-014-0323-5

Abstract: Moreover, some stem cell-based products have been approved for marketing by different national regulatoryexist and need to be urgently addressed, especially in countries where establishment of appropriate regulatorysystem just commenced.More relevantly, the stem cell regulatory sciences need to be established or improved to more effectivelyevaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatory

Keywords： cell-based medicinal products (SCMPs)     stem cell therapy (SCT)     safety     effectiveness     standards     guidelines     regulatory    

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Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 6, doi: 10.1007/s11783-021-1402-x

Abstract: Increasingly, 3re implementation is restricted by regulatory difficulties, particularly the invocation

Keywords： Blockchain     E-waste     Regulatory Policy     Copyright Laws     Repair-Reuse-Remanufacture     Toxicity    

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Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 1,   Pages 3-15 doi: 10.1007/s11783-014-0734-1

Abstract: This critical review focuses on the issues associated with DBP regulatory compliance, including methodsPrecursor removal and alternative disinfectants are common practices for DBP regulatory compliance.

Keywords： Disinfection byproducts (DBPs)     drinking water standards     regulatory compliance     alternative disinfection    

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Liver cell therapies: cellular sources and grafting strategies

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 432-457 doi: 10.1007/s11684-023-1002-1

Abstract: development of genetic sequencing technologies, research on the liver’s cellular composition and its regulatory

Keywords： liver regeneration     hepatocytes     cholangiocytes     stem cells     organoids     regulatory mechanisms     transplantation    

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanismThe regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene
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Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 158-163 doi: 10.1007/s11684-009-0042-5

Abstract: The regulatory effect of basic fibroblast growth factor (bFGF) mediated by recombinant adeno-associatedRegulatory effects of Doxycycline (Dox) on bFGF and osteogenic factors were assayed quantitatively byIt was concluded that rAAV2-tet-off-bFGF could infect MC3T3 cells efficiently, and this recombinant system

Keywords： tetracycline regulatory system     adeno-associated virus     basic fibroblast growth factor     gene regulation    

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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1,   Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract: Regulatory T cells (Tregs) are a subgroup of suppressive CD4+ T cells that play a vital role in the maintenance

Keywords： Regulatory T cells     Cancer     Immunotherapy    

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METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Frontiers of Agricultural Science and Engineering   Pages 215-230 doi: 10.15302/J-FASE-2021382

Abstract: Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanismThe regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene

Keywords： harvest season     metabolites     tea shoots     transcriptomics     untargeted metabolomics    

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Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract:

Regulatory science is a discipline that uses comprehensive methods of natural science, social scienceas H1N1 flu, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS), regulatoryIn particular, with the support of research on drug regulatory science, vaccines have played a majorindustry, research and development (R&D) of COVID-19 vaccines in China, and the general state of regulatoryFurther, this review highlights how regulatory science has promoted the R&D of Chinese COVID-19 vaccines

Keywords： Regulatory science     COVID-19 vaccine     Vaccine industry    

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Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 188-203 doi: 10.15302/J-FASE-2019307

Abstract: Regulatory policies have stagnated due to legal guidelines that could not anticipate the needs and solutionsI propose a new, market-based regulatory model for GM livestock that has both a strong scientific foundation

Keywords： algorithms     editing     FDA     GMO     recombinant DNA     USDA    

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The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection Review

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Engineering 2022, Volume 10, Issue 3,   Pages 21-29 doi: 10.1016/j.eng.2021.10.015

Abstract: However, some macrophage subpopulations, such as regulatory macrophages, can protect allografts fromimmune rejection and promote transplant immune tolerance with their immune regulatory properties.

Keywords： Macrophages     Transplantation     Tolerance     Rejection     Regulatory macrophage    

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The biopharmaceutical industry in China: history and future perspectives

Kai Gao, Junzhi Wang

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 101-111 doi: 10.1007/s11684-012-0191-9

Abstract:

Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US Food and Drug Administration, the biopharmaceutical industry has become the fastest growing, most dynamic and technology-intensive sector in the biomedical field. Since the licensing of recombinant human interferon α1b in 1989, the biopharmaceutical industry in China has gone through initial developments and gradually entered a period of rapid growth. This paper provides an overview of the status and development trends of biopharmaceuticals in China, and compares them with those observed in developed countries.

Keywords： biopharmaceuticals     antibodies     market trends     diseases     China     national regulatory agency    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: In addition, the regulatory elements that control the FIX gene expression in these cassettes

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Review

Bruce R. Blazar

Engineering 2019, Volume 5, Issue 1,   Pages 98-105 doi: 10.1016/j.eng.2018.11.016

Abstract: As our knowledge of immune system homeostasis has increased, cell populations with immune regulatorypreclinical proof of concept of GVHD models, along with GVHD outcomes that focus exclusively on immune regulatory

Keywords： Graft-versus-host disease (GVHD)     Immune regulatory cells     Cell therapy    

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A Study on the Development Strategy for the Prevention of Infectious Diseases in China

Li Lanjuan,Zhang Boli,Xu Jianguo,Du Weibo,Xiao Yonghong,Ma Weihang,Zhang Jianzhong and Zhang Junhua

Strategic Study of CAE 2017, Volume 19, Issue 2,   Pages 37-42 doi: 10.15302/J-SSCAE-2017.02.006

Abstract: It is also necessary to propose a regulatory system and a prevention-and-control research strategy forinternational experience as a reference, this paper proposes strategic measures and suggestions for a regulatorysystem and for prevention-and-control research into infectious diseases in China.This study is based on China’s achievements and challenges of the current system.

Keywords： infectious diseases     regulatory system     prevention-and-control research     strategic suggestion    

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Title Author Date Type Operation

The regulatory sciences for stem cell-based medicinal products

Bao-Zhu Yuan,Junzhi Wang

Journal Article

Zero E-waste: Regulatory impediments and blockchain imperatives

Mengjun Chen, Oladele A. Ogunseitan

Journal Article

Disinfection byproducts in drinking water and regulatory compliance: A critical review

Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE

Journal Article

Liver cell therapies: cellular sources and grafting strategies

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Journal Article

Regulation of exogenous bFGF gene mediated by recombinant adeno-associated virus

Ke SONG, Nianjing RAO, Meiling CHEN, Yingguang CAO

Journal Article

Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy

Feng Xie, Rui Liang, Dan Li, Bin Li

Journal Article

METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN

Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN

Journal Article

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

Zhiming Huang, Zhihao Fu, Junzhi Wang

Journal Article

Regulatory issues for genetically modified animals

Perry Bradbury HACKETT

Journal Article

The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection

Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao

Journal Article

The biopharmaceutical industry in China: history and future perspectives

Kai Gao, Junzhi Wang

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host

Bruce R. Blazar

Journal Article

A Study on the Development Strategy for the Prevention of Infectious Diseases in China

Li Lanjuan,Zhang Boli,Xu Jianguo,Du Weibo,Xiao Yonghong,Ma Weihang,Zhang Jianzhong and Zhang Junhua

Journal Article